At those odds :


Sydney Roosters $3.25 Stake $308
South Sydney Rabbitohs $4.25 Stake $236
Manly Sea Eagles $7.85 Stake $128

Total Outlay : $672.
Potential Profit : $328 (48% POT)

Winner usually comes from top 4.
Odds suggest Penrith can't win.
Cowboys the only real threat

If including cowboys:

North Queensland Cowboys $9 Stake $112

Total Outlay : $784
Potential Profit : $216 (27% POT)